The AOD9604 was initially developed as a fat-burning compound. It is an improved and enhanced version of the HGH fragment 176-191 peptide. Despite primarily focusing on fat-burning benefits, the research compound has shown tremendous benefits in research studies focusing on other sectors like metabolic syndrome, heart disease, and osteoarthritis/cartilage repair. Read and discover more about the chemical composition and properties of AOD9604.
What is AOD-9604?
The AOD-9604 research compound is an improvised version of the hGH fragment 176-191 peptide, meaning it has more potency than its parent compound. The HGH fragment 176-191 peptide has a di-sulfide bridge (a modified piece of growth hormone), making it a derivative of human growth hormone (HGH). Originally the AOD-9604 research compound was developed to function as an anti-obesity medication due to its fat-burning (lipolysis) properties. However, the peptide has become more valuable in clinical research due to its limited effects beyond fat-burning benefits.
The compound doesn’t affect the insulin or IGF-1 level; hence there is no risk of the compound promoting diabetes or glucose intolerance. Additionally, there is no scientific evidence showing the body producing any antibodies to fight the AOD-9604 when ingested; this is because the compound has a chemical structure similar to that of HGH. The chemical structure prevents the stimulation of an immune system response when one consumes the AOD-9604 compound.
Chemical Structure of AOD-9604
- Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe Disulfide bridge Cys7-Cys15
- Molecular Formula: C78H123N23O23S2
- Molecular Weight: 1815.12 g/mol
The AOD-9604 research compound was developed as an analogue version of the HGH to deal with fighting fat. Regardless, the compound has gained more attention by having more potential clinical benefits than initiating fat loss. Let’s look at the reproach studies, which have primarily focused on the AOD-9604 research chemical.
AOD-9604 and Obesity
The AOD-9604 phase II clinical trials were finished in Australia and involved 300 obese individuals. During the trial, the subjects were given a daily administration of the drug for 12 weeks. At the end of the trial, results confirmed that the drug triggered a triple weight loss effect than the placebo compound. Also, the rate of weight loss remained constant during the trial phase period, and the latter fact indicates that long-term use of the research chemical will even trigger more significant weight loss results, and there is minimal chance of the body developing resistance to the peptide.
Research on obese mice revealed that the AOD-9604 compound doesn’t trigger weight loss by only targeting the beta-3-adrenergic receptors in white fat. Obese mice without the beta-3-adrenergic receptors still experienced fat loss when the compound was administered.
Joint Function and Pain
Previous studies on mice showed that injecting the AOD-9604 compound directly into joints affected by arthritis worked in synergy with other therapy treatments to reduce pain, reduce disability. Changes in the cartilage’s microscopic structures indicate that AOD-9604 can function as a preventative and treatment drug for arthritis. Even though the compound effectively works well in treating joint dysfunction, it triggers optimal results when combined with other treatment therapies.
Weight loss and fat reduction have been considerably associated with reduced cardiovascular health risks. Scientific evidence suggests that the AOD-9604 compound might have additional benefits to the cardiovascular system beyond weight loss. It is recommended that since the research compound operates independent of the beta-3-adrenergic receptor activation, it can enhance metabolic metrics while triggering fat loss.
AOD-9604 has been associated with manageable side effects. The compound exhibited high oral and impressive subcutaneous bioavailability when tested on mice. However, the per kg mice dosage doesn’t scale to humans. Despite the fantastic suggested health benefits of the compound, it is only available for scientific research and education purposes and not available for human consumption. The purchase of the research compound is only available for licensed researchers.
AOD-9604 can be one of the best treatments for obesity in the health sector. More studies are still undergoing to explore the full potential of the compound.