Cardiovascular diseases are among the most terminal illnesses in human history. Researchers and doctors are spending a lot of resources and time trying to find a cure and effective medication for various heart illnesses. Hexarelin is an artificial analogue of ghrelin with great potential to help patients with cardiac ischemia and heart disease recover faster from a heart attack. Read on to learn more about the potential benefits of Hexarelin in overall human health.
What Is Hexarelin?
The Hexarelin compound is an artificial analogue of ghrelin, also known as Examorelin. It is closely related to the GHRP-6 research compound, with the only difference between the two compounds being the presence of two methyl groups on the chemical structure of GHRP-6. Like most of the analogues of ghrelin, the Examorelin compound is administered orally and is highly selective and sublingually active. The compound has been heavily researched to determine its effectiveness in treating various heart conditions and reducing their effects. The primary focus of the research studies has been nutrient deprivation and how the heart cells are affected after an ischemic incident.
Hexarelin Chemical Structure
- Chemical Sequence: His-D-Trp (2-Me)-Ala-Trp-D-Phe-Lys
- Molecular Formula: C47H58N12O6
- Molecular Weight: 887.059 g/mol
Hexarelin Research and Effects
Protecting the Heart
The Examorelin compound directly affects the heart. It binds to the growth hormone secretagogue receptor (GHSR) and the CD36 receptor. According to research studies done on mice, the compound protects heart cells after a heart attack when it binds to the two receptors. The compound, in turn, prevents the heart cells from undergoing programmed cell death (apoptosis). During the study, the mice treated using Examorelin exhibited improved heart function, reduced production of malondialdehyde and a higher number of surviving heart cells. Findings from the study also showed that GHRP-6 was more potent than Hexarelin.
The mechanism used by the Hexarelin compound in protecting the heart cells remains unspecified as to how the heart cells are damaged at the onset of a heart attack. Researchers are now considering looking into ways in which the peptide compound can be used in protecting the heart from other conditions. Additional studies on rats have shown that the Hexarelin compound enhanced the cardiac function in a diabetes model by altering how the heart cells changed the calcium and potassium processing.
Improving Fat Measures
Dyslipidemia is a medical condition which refers to the abnormal fat amount or concentration in the blood. Researchers have discovered that the condition is an independent risk and causal factor of diabetes in anyone, including thin and healthy individuals. They have significantly associated the condition with increasing diabetes cases in first-world countries. More studies are being done to understand the effects of Dyslipidemia on human psychology, how the condition impacts overall health and whether the modern diet is triggering it.
According to research studies on rats, GHRP-6 can help create a Dyslipidemia condition when the body faces insulin resistance, which is usually the first stage of diabetes. It can also lower insulin resistance and blood sugar levels. The Examorelin compound is a more reliable treatment option for current lipid medications in treating severe Dyslipidemia.
Protecting the Muscle
Apart from protecting the heart muscles from programmed cell death, the Examorelin peptide compound can protect other muscles in the body. Several research studies were done on rats suffering from cachexia, which is extreme weight loss due to chemotherapy and illness. The peptide was found to protect the muscles by regulating calcium flow and mitochondrial dysfunction. The mitochondrial cells are plant cells; without these power cells, a plant cannot produce the energy they need to carry out various functions and hence die.
During chemotherapy treatment, calcium production in the body is disrupted, which in turn causes calcium dysregulation. Calcium dysregulation during chemotherapy affects lean muscle mass growth in the body. Findings from the study showed that the peptide could be used in protecting the body’s muscles since it offsets the changes in calcium regulation triggered by chemotherapy.
Cardiovascular health and illnesses are among the most refreshed aspects of human health. Heart diseases are among the leading causes of death, especially in developed countries. Doctors and researchers spend a lot of time and resources trying to fully understand the complex process that triggers heart disease and heart failure. However, with the creation of artificial peptides like Hexarelin, the future looks very promising. Research studies on the Examorelin peptide compound have revealed various pathways which can be used in understanding the heart’s function in diseases and overall health.
Additionally, the Examorelin peptide compound has opened doors to new treatment options which are more effective in improving overall cardiovascular health. During the various research studies on mice and rats, the compound exhibited moderate side effects, excellent subcutaneous bioavailability and low oral. Currently, the compound is only sold to licensed researchers and used only for research and educational purposes. Currently, the compound isn’t available for human consumption.
The Examorelin peptide compound has great potential in treating and improving the overall health of human beings by protecting the heart cells and muscles. More research studies are being done on the compound to determine more health benefits.