THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should on be handled by licensed, qualified professionals.

SKU: Selank Category:


Physical Appearance Fine White Lyophilized Powder
Residue Sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro
Solubility 100 ug/mL sterile diluent (distilled de-ionized water)
Purity >99%
Stability Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.

About Selank

Selank is an artificial compound, which is an analog of Tuftsin with profound anti-anxiety capabilities. According to various scientific studies, the compound has several health benefits ranging from boosting learning and memory to beneficial effects on the body’s pain receptors. But what is Selank, and how are scientists and researchers utilizing it in dealing with various health conditions?

What is Selank?

Selank is a short peptide developed in Russia. It’s an artificial analog of Tuftsin and possesses anxiolytic and nootropic properties. Tuftsin is a naturally occurring immunomodulatory peptide found in the body, and its primary role is modulating:

  • Interleukin 6 (IL-6)
  • Monoamine neurotransmitters
  • T helper cells
  • Brain-derived neurotrophic factor (BDNF

Selank and Tuftsin have significant similarities, the key difference being their chemical structure. The Selank peptide has four amino acids, enhancing its half-life and improving metabolic stability. Several research studies have been conducted to determine the viability of Selank in being a possible treatment option for generalized anxiety disorder.

Selank Chemical Structure

  • Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
  • Molecular Formula: C33H57N11O9
  • Molecular Weight: 751.887 g/mol
  • Synonyms: Selanc

Selank Research and Effects

Genes Based Anxiety Effects Caused by GABA Neurotransmitter

Dr. Anastasiya Volkova from the Russian Institute of Molecular Genetics is one of the top researchers in the world who has an extreme interest in Selank. Volkova stated that many studies have concluded that Selank can be a viable treatment option for anxiety because it has strong neuroprotective and anti-anxiety effects. The research studies show that the peptide compound has the same effects as classical anti-anxiety medications like benzodiazepine. Classical anti-anxiety medications are allosteric modulators of the body’s GABAA receptors, increasing the receptor’s inhibitory actions.

Apart from that, Selank also has other effects on the body:

  • Lowering the stress levels
  • Improving the mood
  • Reducing anxiety
  • Positively influencing learning and memory.

Selank has the same benefits as anti-anxiety medications like benzodiazepine. Additionally, when administered in low doses, it causes a sedating effect like benzodiazepine. The one benefit of using Selank and not like benzodiazepine or other anti-anxiety medications, it’s that it doesn’t cause a habit-forming dependency on the medication. Patients also don’t have to deal with amnesia and withdrawal symptoms when they stop using the Selank peptide.

A research study was done on 84 rats with GABA signaling. Seven rats were heavily modulated with the Selank peptide, while 45 more showed improvement in expression after administration of Selank. Findings from the study showed that Selank affected 52 genes directly connected to GABA signaling. Thus, the peptide can directly affect gene expression in the nerve cells. It is capable of causing changes to the body by altering the GABA receptor’s affinity to GABA, which explains why Selank has the same functionality as anti-anxiety medications and GABA receptor agonists.

Another research study revealed that when Selank and benzodiazepine are used independently, they trigger the same effects on anxiety and reduce the effects of generalized anxiety disorder. Even though Selank is more advantageous than benzodiazepine, researchers believe combining the two medications will be most effective in treating anxiety and unpredictable chronic mild stress.

Selank affects enkephalin degradation, allowing researchers to modulate GABA receptors’ peptides. According to various tests conducted by doctors, patients with phobic and anxiety disorders experience increased enkephalinase activity. The reaction happens in the bloodstream when they are under stress, and the enkephalin produced has shorter half-lives. Selank can trigger enkephalinase inhibition, thus preventing enkephalin from degrading. Scientists believe the peptide could rest the enzymatic pathway and protect the natural anxiolytic peptides. The hypothesis was supported by a research study on mice prone to anxiety. Findings from the study confirmed that the Selank peptide prevented enkephalin degradation.

Immune System and Anxiety

Researchers did a study on patients with suffering and the possible effects of Selank on their condition. They discovered that the Selank peptide could suppress the causal gene, which enhances the inflammatory cytokine IL-6’s production in the body. The effect was observed only in patients suffering from depression, not in healthy individuals. Scientists concluded that Selank could be used in treating anxiety-asthenic disorders. Doctors can also use it in treating anxiety disorders caused by fatigue, high blood pressure, headache, depression, heart palpitations, and nerve pain.

When Selank treatment was compared to the standard anxiolytic treatments (benzodiazepines), they discovered that the peptide treatment didn’t cause any asthenic symptoms like pain or fatigue. The effect was linked to Selank’s ability to modulate IL-6 expression and alter the breakdown rate of the naturally occurring painkillers (enkephalin)

When Selank was tested in rats, scientists observed that the peptide regulated the expression of 34 genes in the body, which affect the inflammatory process. The 34 genes affected chemokines, cytokines, and their respective receptors. Recent discoveries show that Selank changes the expression of the BcI6, which is responsible for immune system development. Additionally, the study revealed that Selank has complex biological effects on the immune system and can help researchers understand how the immune system develops.

When administered to mice, Selank altered the gene expression for Xcr1, C3, CAsp1, and Il2rf in the mice’s spleen. By affecting the expression of these genes, Selank can regulate the immune system’s balance, thus modulating inflammation.

Memory and Learning

Scientific evidence shows a deep connection between anxiety and learning/memory. The correlation between these two key factors is adverse; increased anxiety negatively affects learning and memory. Increased anxiety reduces our ability to remember things and even absorb new information. Traditional anti-anxiety medication can help in reversing these effects. But Selank has more benefits than simply reducing how anxiety negatively affects cognitive function. Researchers suspect that Selank can directly boost cognitive ability.

In a research study involving rats trained with food rewards, after the administration of Selank, the rats experienced enhanced memory trace stability. Thus improving the memory storage process. The rats exhibited the effects despite having different anxiety levels, confirming that Selank has an effect beyond stress reduction and memory impairment correction.

Additional research suggests that Selank can be used in rescuing memory and learning after brain damage. Rats that were treated with neurotoxin and Selank experienced restored cognitive processes. The effect was connected to the catecholamine system artificial inhibition caused by Selank. There is hope that the peptide can be used to treat traumatic brain injury, especially during childbirth.


The Selank peptide can reduce enkephalin’s degradation by inhibiting the enzyme. The enzymes in the bloodstream break down the naturally occurring enkephalin. Enkephalin is a naturally occurring peptide found in the body, which helps reduce pain severity by binding to opioid receptors. They also help manage human stress and are observed in high quantities in the adrenal glands and brain when one is under stress. When Selank reduces the level of enkephalin in the brain, it can timely blunt the regular stress response. Hence preventing any adverse effects of stress on memory, concentration, and learning.

Selank is one of the most revolutionary peptides in treating stress and anxiety. Unlike regular anti-anxiety medication, the peptide triggers the same health benefits without causing any side effects associated with the anti-anxiety medication. Apart from that, the peptide plays a crucial role in boosting memory, concentration, and learning, which is frequently affected by stress. Ongoing studies look at how the peptide can be used to improve neuro health and reduce pain. When Selank was administered to mice, it exhibited excellent subcutaneous bioavailability, minimal side effects, and low oral. There is no scientific evidence on the possible side effects of Selank on humans since you can’t scale the dosage used in mice to humans.

Selank is a promising peptide for treating anxiety, stress, and other complications. Unfortunately, the compound isn’t available for human consumption at the moment, and it’s only used for research purposes.

Additional information

Weight 0.04 kg

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