SLU PP 332

About SLU PP 332

SLU-PP-332 is a synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ), nuclear receptors that regulate energy metabolism. This compound has garnered attention in biomedical research for its potential to enhance mitochondrial function and mimic the metabolic effects of exercise, earning it the moniker “exercise in a pill.” By activating ERR pathways, SLU-PP-332 may support studies related to metabolic disorders, muscle function, and aging.

What is SLU-PP-332?

SLU-PP-332 is a small-molecule agonist that binds to estrogen-related receptors, particularly exhibiting high affinity for ERRα with an EC₅₀ of 98 nM, and moderate affinity for ERRβ and ERRγ with EC₅₀ values of 230 nM and 430 nM, respectively. Activation of these receptors leads to increased expression of genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation. In preclinical studies, SLU-PP-332 has been shown to enhance mitochondrial respiration, increase type IIa oxidative muscle fibers, and improve exercise endurance in skeletal muscle cell lines and animal models.

• Enhances mitochondrial function and cellular respiration
• Increases oxidative muscle fiber composition
• Improves exercise tolerance in preclinical models
• Potential applications in metabolic disease and aging research

Chemical Structure of SLU-PP-332

• Application: Pan-agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ)
• CAS: 303760-60-3
• Molecular Weight: 290.32 g/mol
• Chemical Formula: C₁₈H₁₄N₂O₂
• Chemical Name: (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide